Description
FOXO4-DRI is a synthetic retro-inverso peptide constructed from the FOXO4 forkhead domain sequence, designed to competitively disrupt the FOXO4-p53 protein-protein interaction. Because it is a D-amino-acid retro-inverso peptide with a cell-penetrating carrier sequence, reported molecular weights vary across sources (approximately 3-5 kDa), and no single formula or CAS number is consistently reported in the literature; specifications should be confirmed against the certificate of analysis for this batch.
Preclinical research on FOXO4-DRI has examined its ability to selectively induce apoptosis in senescent cells by displacing nuclear p53 sequestered by FOXO4, with downstream effects studied in cell culture and animal senescence models.
Supplied as a lyophilized powder for reconstitution, each batch is analyzed by HPLC to confirm purity.
For laboratory research use only. Not for human or veterinary use, and not intended for diagnostic or therapeutic application.
